Circadian Metabolism: From Mechanisms to Metabolomics and Medicine

The circadian clock directs nearly all aspects of diurnal physiology, including metabolism. Current research identifies several major axes by which it exerts these effects, including systemic signals as well as direct control of cellular processes by local clocks. This redundant network can transmit...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2016-06, Vol.27 (6), p.415-426
Main Author: Brown, Steven A
Format: Article
Language:English
Subjects:
Animals
chronopharmacology
Circadian Clocks - genetics
Circadian Clocks - physiology
circadian genes
Circadian Rhythm - genetics
Circadian Rhythm - physiology
diabetes
diet
drug screening
Endocrinology & Metabolism
Energy Metabolism - genetics
Energy Metabolism - physiology
Homeostasis
Humans
lipidomics
metabolomics
Metabolomics - methods
mitochondria
Mitochondria - metabolism
obesity
redox homeostasis
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Summary:The circadian clock directs nearly all aspects of diurnal physiology, including metabolism. Current research identifies several major axes by which it exerts these effects, including systemic signals as well as direct control of cellular processes by local clocks. This redundant network can transmit metabolic and timing information bidirectionally for optimal synchrony of metabolic processes. Recent advances in cellular profiling and metabolomics technologies have yielded unprecedented insights into the mechanisms behind this control. They have also helped to illuminate individual variation in these mechanisms that could prove important in personalized therapy for metabolic disease. Finally, these technologies have provided platforms with which to screen for the first potential drugs affecting clock-modulated metabolic function.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2016.03.015