Efficient method for the synthesis of diphosphine ligands with a heteroaryl–aryl bridge

A new efficient method for the synthesis of heteroaryl–aryl diphosphine ligands by direct double metallation of heteroaryl–aryls followed by phosphorylation of the resulting o, o′-dilithium salts is described. A number of new C 1-symmetric diphosphine ligands based on 3-arylheteroaryls, X-heteroaryl...

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Bibliographic Details
Published in:Tetrahedron 2004-11, Vol.60 (45), p.10365-10370
Main Authors: Artemova, Nataliya V., Chevykalova, Marina N., Luzikov, Yuri N., Nifant'ev, Ilya E., Nifant'ev, Eduard E.
Format: Article
Language:English
Subjects:
Diphosphines
Heterocycles
Indole
Phosphorylation
Thiophene
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Summary:A new efficient method for the synthesis of heteroaryl–aryl diphosphine ligands by direct double metallation of heteroaryl–aryls followed by phosphorylation of the resulting o, o′-dilithium salts is described. A number of new C 1-symmetric diphosphine ligands based on 3-arylheteroaryls, X-heteroaryls (X=N), and diphosphine ligands with a heterocyclic bridge with o-tolyl as the aryl fragment have been synthesized. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.07.082