Pyridazine derivatives. Part 40: Reactivity of 5-alkynylpyridazin-3(2 H)-ones toward hydrochloric acid

5-Alkynylpyridazin-3(2 H)-ones or 5-(2-chloroalkenyl)pyridazin-3(2 H)-ones were isolated during the cleavage of the methoxymethyl group in a series of 5-alkynyl-2-methoxymethylpyridazin-3(2 H)-ones by treatment with hydrochloric acid. The efficient and selective cleavage of the methoxymethyl group i...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2005-05, Vol.61 (20), p.4785-4791
Main Authors: Coelho, Alberto, Novoa, Héctor, Peeters, Oswald M., Blaton, Norbert, Alvarado, Mario, Sotelo, Eddy
Format: Article
Language:English
Subjects:
Electrophilic addition
Protecting groups
Pyridazinones
X-ray diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:5-Alkynylpyridazin-3(2 H)-ones or 5-(2-chloroalkenyl)pyridazin-3(2 H)-ones were isolated during the cleavage of the methoxymethyl group in a series of 5-alkynyl-2-methoxymethylpyridazin-3(2 H)-ones by treatment with hydrochloric acid. The efficient and selective cleavage of the methoxymethyl group in these compounds can be performed under mild conditions by employing aluminium chloride. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.03.021