Fluorescence modification of Gb3 oligosaccharide and rapid synthesis of oligosaccharide moieties using fluorous protective group

The use of the bisfluorous chain-type propanoyl (Bfp) group as a fluorous protective group made it possible to rapidly synthesize the Gb2 and Gb3 oligosaccharide derivatives by a simple fluorous-organic extraction purification. Furthermore, the fluorescence-labeled Gb2 and Gb3 oligosaccharides were...

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Bibliographic Details
Published in:Tetrahedron 2005-07, Vol.61 (27), p.6518-6526
Main Authors: Miura, Tsuyoshi, Tsujino, Satoshi, Satoh, Ai, Goto, Kohtaro, Mizuno, Mamoru, Noguchi, Midori, Kajimoto, Tetsuya, Node, Manabu, Murakami, Yasuoki, Imai, Nobuyuki, Inazu, Toshiyuki
Format: Article
Language:English
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Summary:The use of the bisfluorous chain-type propanoyl (Bfp) group as a fluorous protective group made it possible to rapidly synthesize the Gb2 and Gb3 oligosaccharide derivatives by a simple fluorous-organic extraction purification. Furthermore, the fluorescence-labeled Gb2 and Gb3 oligosaccharides were prepared as a potential Vero Toxins detecting reagent. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.05.001