New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum

Chemical investigations of the ascidian Didemnum obscurum has resulted in the isolation of four new lamellarin alkaloids, lamellarin-ζ ( 1 ), lamellarin-η ( 2 ), lamellarin-ϕ ( 3 ) and lamellarin-χ ( 4 ) along with seven known lamellarins, lamellarin-K ( 5 ), lamellarin-I ( 6 ), lamellarin-J ( 7 ),...

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Bibliographic Details
Published in:Tetrahedron 2005-09, Vol.61 (39), p.9242-9247
Main Authors: Malla Reddy, S., Srinivasulu, M., Satyanarayana, N., Kondapi, Anand K., Venkateswarlu, Y.
Format: Article
Language:English
Subjects:
Ascidians
Coloractal cancer cells
Cytotoxic activity
Lamellarin alkaloids
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Summary:Chemical investigations of the ascidian Didemnum obscurum has resulted in the isolation of four new lamellarin alkaloids, lamellarin-ζ ( 1 ), lamellarin-η ( 2 ), lamellarin-ϕ ( 3 ) and lamellarin-χ ( 4 ) along with seven known lamellarins, lamellarin-K ( 5 ), lamellarin-I ( 6 ), lamellarin-J ( 7 ), lamellarin-K triacetate ( 8 ), lamellarin-L triacetate ( 9 ), lamellarin-F ( 10 ) and lamellarin-T diacetate ( 11 ). The structures of the compounds 1– 11 were established by detailed analysis of NMR spectral data. Cytotoxic activity of the isolates has been done against coloractal cancer cells. Four new and several known lamellarin alkaloids have been isolated and characterized by the study of their spectral data. Cytotoxic activity against coloractal cancer cell lines has been evaluated.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.07.067