Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

A simple route to 1- R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying...

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Bibliographic Details
Published in:Tetrahedron 2007-01, Vol.63 (2), p.474-491
Main Authors: Butin, Alexander V., Smirnov, Sergey K., Stroganova, Tatyana A., Bender, Wolfgang, Krapivin, Gennady D.
Format: Article
Language:English
Subjects:
Furan
Indoles
Recyclization
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Summary:A simple route to 1- R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2006.10.056