Direct coupling of arenes and iodoarenes catalyzed by a rhodium complex with a strongly π-accepting phosphite ligand

A new rhodium-based catalytic system for the direct C–H coupling of arenes and iodoarenes that shows high activity with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF 3) 2] 3} 2 and Ag 2CO 3, the direct C–H arylation of heteroarenes and arenes took place wit...

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Bibliographic Details
Published in:Tetrahedron 2008-06, Vol.64 (26), p.6073-6081
Main Authors: Yanagisawa, Shuichi, Sudo, Tomoko, Noyori, Ryoji, Itami, Kenichiro
Format: Article
Language:English
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Summary:A new rhodium-based catalytic system for the direct C–H coupling of arenes and iodoarenes that shows high activity with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF 3) 2] 3} 2 and Ag 2CO 3, the direct C–H arylation of heteroarenes and arenes took place with iodoarenes to afford a range of biaryls in good to excellent yields with high regioselectivity. Thiophenes, furans, pyrroles, indoles, and alkoxybenzenes are applicable to this arylation protocol. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2008.01.053