Practical synthesis of a peptidomimetic thrombin inhibitor

Compound 1 is a low molecular weight thrombin inhibitor developed for treatment of deep vein thrombosis and cardiovascular diseases. We herein report our efforts to develop a robust, efficient and reproducible process suitable for large-scale synthesis of compound 1. [Display omitted]

Saved in:
Bibliographic Details
Published in:Tetrahedron 2009-03, Vol.65 (13), p.2689-2694
Main Authors: Wilmouth, Serge, Bufferne-Perret, Christel, Flouzat, Christine, Humblot, Grégoire, Ray, Christiane, Simbille, Nadine
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Impurity identification
Low molecular weight thrombin inhibitor
Organic chemistry
Peptides
Peptidomimetic
Preparations and properties
Process development and scale-up
α-Hydroxy amide oxidation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Compound 1 is a low molecular weight thrombin inhibitor developed for treatment of deep vein thrombosis and cardiovascular diseases. We herein report our efforts to develop a robust, efficient and reproducible process suitable for large-scale synthesis of compound 1. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2009.01.078