Isolation and total syntheses of two new alkaloids, dubiusamines-A, and -B, from Pandanus dubius

Chemical investigation of the crude base of Pandanus dubius led to the isolation of two new alkaloids, dubiusamine-A ( 1) and dubiusamine-B ( 2). The structures of the two alkaloids including their absolute configuration were unambiguously confirmed by 1D and 2D NMR analysis and asymmetric total syn...

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Bibliographic Details
Published in:Tetrahedron 2010-05, Vol.66 (18), p.3353-3359
Main Authors: Tan, Mario A., Kitajima, Mariko, Kogure, Noriyuki, Nonato, Maribel G., Takayama, Hiromitsu
Format: Article
Language:English
Subjects:
Alkaloid
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Isolation
Organic chemistry
Pandanus
Preparations and properties
Total synthesis
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Summary:Chemical investigation of the crude base of Pandanus dubius led to the isolation of two new alkaloids, dubiusamine-A ( 1) and dubiusamine-B ( 2). The structures of the two alkaloids including their absolute configuration were unambiguously confirmed by 1D and 2D NMR analysis and asymmetric total synthesis. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2010.02.073