Palladium-catalyzed oxidative alkynylation of arene C–H bond using the chelation-assisted strategy

Palladium-catalyzed alkynylation of arene C–H bonds with (triisopropylsilyl)acetylene was developed for the first time under oxidative conditions in the present study. Among various type of directing groups examined, the N-phenyl-2-aminopyridine skeleton was shown to be most effective and selective...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2012-07, Vol.68 (26), p.5162-5166
Main Authors: Kim, Seok Hwan, Park, Sae Hume, Chang, Sukbok
Format: Article
Language:English
Subjects:
Alkynylation
Chelation-assistance
C–H bond activation
Oxidative coupling
Palladium catalyst
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Palladium-catalyzed alkynylation of arene C–H bonds with (triisopropylsilyl)acetylene was developed for the first time under oxidative conditions in the present study. Among various type of directing groups examined, the N-phenyl-2-aminopyridine skeleton was shown to be most effective and selective for the Pd-catalyzed direct alkynylation reaction, and the desired alkynylated products were obtained in moderate to good yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2012.04.003