Synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component reaction in poly(ethylene glycol)

An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I2 and K2S2O8 in the presence of Na2CO3 was u...

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Bibliographic Details
Published in:Tetrahedron 2012-08, Vol.68 (33), p.6721-6726
Main Authors: Zareai, Zeinab, Khoobi, Mehdi, Ramazani, Ali, Foroumadi, Alireza, Souldozi, Ali, Ślepokura, Katarzyna, Lis, Tadeusz, Shafiee, Abbas
Format: Article
Language:English
Subjects:
4-Hydroxycoumarin
Chemistry
Exact sciences and technology
Furo[3,2-c]coumarin
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Multicomponent reaction
Organic chemistry
Oxidation
Poly(ethylene glycol)
Preparations and properties
X-ray single crystal structure analysis
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Summary:An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I2 and K2S2O8 in the presence of Na2CO3 was used as an oxidative reagent. The structure of the furo[3,2-c]coumarins was established by X-ray single crystal structure analysis. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2012.05.112