Synthesis of the northern fragment of an epothilone D analogue from (−)-carvone

A simple and effective synthesis of the chiral thiazole-containing fragment of an epothilone D analogue from (−)-carvone is described. [Display omitted]

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Bibliographic Details
Published in:Tetrahedron 2012-08, Vol.68 (34), p.6868-6872
Main Authors: Valeev, Ruslan F., Bikzhanov, Radmir F., Yagafarov, Niyaz Z., Miftakhov, Mansur S.
Format: Article
Language:English
Subjects:
Carvone
Epothilones
Oxidative cleavage
Rubottom methodology
Thiazole-containing fragment
Wittig olefination
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Description
Summary:A simple and effective synthesis of the chiral thiazole-containing fragment of an epothilone D analogue from (−)-carvone is described. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2012.06.020