A method for the regioselective synthesis of 1-alkyl-1H-indazoles

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination. [Display omitte...

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Bibliographic Details
Published in:Tetrahedron 2013-05, Vol.69 (19), p.3907-3912
Main Authors: Liu, Han-Jun, Hung, Shiang-Fu, Chen, Chuan-Lin, Lin, Mei-Huey
Format: Article
Language:English
Subjects:
2-Halobenzonitriles
Deamination
Indazoles
N-Alkylhydrazines
Regioselective
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Description
Summary:A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.03.042