Synthesis and hyperpolarized 15N NMR studies of 15N-choline-d13

15N-Choline-d13 was synthesized as a new biomarker for dynamic nuclear polarization, and the lifetime of the polarized signal governed by the spin–lattice relaxation time T1 was measured. 15N-Choline-d13 exhibited a T1 that was over twice as long as that of 15N-choline, and the hyperpolarized 15N si...

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Bibliographic Details
Published in:Tetrahedron 2013-05, Vol.69 (19), p.3896-3900
Main Authors: Kumagai, Keiko, Kawashima, Kazuyasu, Akakabe, Mai, Tsuda, Masayuki, Abe, Takamasa, Tsuda, Masashi
Format: Article
Language:English
Subjects:
Choline
Dynamic nuclear polarization
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Summary:15N-Choline-d13 was synthesized as a new biomarker for dynamic nuclear polarization, and the lifetime of the polarized signal governed by the spin–lattice relaxation time T1 was measured. 15N-Choline-d13 exhibited a T1 that was over twice as long as that of 15N-choline, and the hyperpolarized 15N signal could be observed for 1 h. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.03.043