Rubischumanins A–C, new cytotoxic cyclopeptides from Rubia schumanniana

Three new cyclic hexapeptides, designated as rubischumanins A–C (1–3), together with three known ones (4–6) were isolated from the roots and rhizomes of Rubia schumanniana. The structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of these compounds was evaluated...

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Bibliographic Details
Published in:Tetrahedron 2014-10, Vol.70 (42), p.7627-7631
Main Authors: Huang, Mao-Bo, Zhao, Si-Meng, Zeng, Guang-Zhi, Kuang, Bin, Chen, Xiao-Qiang, Tan, Ning-Hua
Format: Article
Language:English
Subjects:
Cyclopeptides
Cytotoxicity
Rubia schumanniana
Rubischumanins A–C
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Summary:Three new cyclic hexapeptides, designated as rubischumanins A–C (1–3), together with three known ones (4–6) were isolated from the roots and rhizomes of Rubia schumanniana. The structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of these compounds was evaluated and compounds 1, 2, 4, and 5 showed cytotoxicity against A549, BGC-823, and Hela cell lines. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.07.105