A novel and efficient synthesis of diamino derivatives of pyrano[3,4-c]pyridines

The new and effective method for the synthesis of diamino substituted pyrano[3,4-c]pyridines was developed, based on recyclization of the pyridine ring. As initial compounds 6-aminopyrano[3,4-c]pyridine-2(1H)-thiones 4а–е were used. The X-ray crystallographic analysis showed the presence of intramol...

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Bibliographic Details
Published in:Tetrahedron 2015-05, Vol.71 (18), p.2686-2691
Main Authors: Paronikyan, Ervand G., Dashyan, Shushanik Sh, Noravyan, Azat S., Tamazyan, Rafael A., Ayvazyan, Armen G., Panosyan, Henrik A.
Format: Article
Language:English
Subjects:
Antimicrobial activity
Pyrano[3,4-c]pyridines
Pyridinium salts
Rearrangement
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Summary:The new and effective method for the synthesis of diamino substituted pyrano[3,4-c]pyridines was developed, based on recyclization of the pyridine ring. As initial compounds 6-aminopyrano[3,4-c]pyridine-2(1H)-thiones 4а–е were used. The X-ray crystallographic analysis showed the presence of intramolecular and intermolecular hydrogen bonds in the diamino derivative 6k. The synthesized compounds were analyzed for the antimicrobial activity. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2015.03.040