A straightforward enantioselective synthesis of F17807

An efficient approach for the enantioselective synthesis of the 1,4-benzodioxane F17807 drug is reported. The developed route relied on two key steps, namely SNAr and Mitsunobu reactions, which permitted a straightforward access to the title compound with full preservation of the enantiomeric excess...

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Bibliographic Details
Published in:Tetrahedron 2015-12, Vol.71 (50), p.9383-9387
Main Authors: Alliot, Julien, Gravel, Edmond, Buisson, David-Alexandre, Larquetoux, Laurent, Nicolas, Marc, Doris, Eric
Format: Article
Language:English
Subjects:
Benzodioxane
Enantioselective synthesis
Mitsunobu
SNAr
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Summary:An efficient approach for the enantioselective synthesis of the 1,4-benzodioxane F17807 drug is reported. The developed route relied on two key steps, namely SNAr and Mitsunobu reactions, which permitted a straightforward access to the title compound with full preservation of the enantiomeric excess throughout the synthetic sequence. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2015.10.065