Brønsted acid promoted one-pot synthesis of 4-aryl-3,4-dihydrocoumarins

4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Brønsted acid catalyzed Friedel–Crafts alkylation and cycloa...

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Bibliographic Details
Published in:Tetrahedron 2016-07, Vol.72 (27-28), p.3917-3921
Main Authors: Chen, Cheng, Zhang, Rui, Lin, Long, Yang, Guang-Fu, Wu, Qiong-You
Format: Article
Language:English
Subjects:
Brønsted acid
Cycloaddition
Dihydrocoumarins
Friedel–Crafts alkylation
Perchloric acid
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Summary:4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Brønsted acid catalyzed Friedel–Crafts alkylation and cycloaddition reaction. With this protocol, 15 examples of 4-aryl-3,4-dihydrocoumarins were successfully prepared with yields ranging from 82 to 99%. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.05.007