l-Proline catalyzed four-component one-pot synthesis of coumarin-containing dihydropyrano[2,3-c]pyrazoles under ultrasonic irradiation

A simple and convenient approach to the synthesis of coumarin-containing dihydropyrano[2,3-c]pyrazoles via four-component reaction of β-dicarbonyl compound, phenylhydrazine, aromatic aldehydes and malononitrile in EtOH catalyzed by l-proline under ultrasonic irradiation is described. The reaction gi...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2016-11, Vol.72 (47), p.7599-7605
Main Authors: Seydimemet, Mengnisa, Ablajan, Keyume, Hamdulla, Mawjvda, Li, Wenbo, Omar, Adil, Obul, Mamateli
Format: Article
Language:English
Subjects:
Coumarin
Dihydropyrano[2,3-c]pyrazole
l-Proline
Multi-component reaction
One-pot synthesis
Ultrasound irradiation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple and convenient approach to the synthesis of coumarin-containing dihydropyrano[2,3-c]pyrazoles via four-component reaction of β-dicarbonyl compound, phenylhydrazine, aromatic aldehydes and malononitrile in EtOH catalyzed by l-proline under ultrasonic irradiation is described. The reaction gives the coumarin-containing dihydropyrano[2,3-c]pyrazoles in good to excellent yields at room temperature. This method provides several advantages, such as shorter reaction time, environmental friendliness, simple workup procedure and higher yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.10.016