Iodine-catalyzed aerobic oxidation of o-alkylazoarenes to 2H-indazoles

An iodine-catalyzed aerobic-oxidative C-H functionalization of o-alkylazoarenes to afford 2H-indazoles has been developed. CuI was found to be an effective additive to accelerate the regeneration of iodine in the catalytic cycle. This catalytic system is suitable for both electron-rich and electron-...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2017-03, Vol.73 (10), p.1311-1316
Main Authors: Yi, Xiangli, Xi, Chanjuan
Format: Article
Language:English
Subjects:
2H-indazole
Aerobic oxidation
Iodine catalysis
sp3 C-H functionalization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An iodine-catalyzed aerobic-oxidative C-H functionalization of o-alkylazoarenes to afford 2H-indazoles has been developed. CuI was found to be an effective additive to accelerate the regeneration of iodine in the catalytic cycle. This catalytic system is suitable for both electron-rich and electron-deficient azoarenes and tolerates a variety of functional groups with high yields. A gram-scale reaction was successfully conducted, proving the scalability of this reaction. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2017.01.035