Multicomponent assembling of imidazole N-oxides, aldehydes and CH-acids: A simple and efficient approach to newly functionalized imidazole derivatives

An efficient and simple method for C2-functionalization of 2-unsubstituted imidazole N-oxides has been developed. It consists at the condensation of 2-unsubstituted imidazole N-oxides with aldehydes and CH-acids. This method permits broad variations in the structure of starting materials. [Display o...

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Bibliographic Details
Published in:Tetrahedron 2017-11, Vol.73 (47), p.6669-6675
Main Authors: Mityanov, Vitaly S., Kutasevich, Anton V., Krayushkin, Michail M., Lichitsky, Boris V., Dudinov, Arkady A., Komogortsev, Andrey N., Koldaeva, Tatyana Yu, Perevalov, Valery P.
Format: Article
Language:English
Subjects:
CH-acids
CH-functionalization
Imidazole N-oxides
Multicomponent reaction
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Summary:An efficient and simple method for C2-functionalization of 2-unsubstituted imidazole N-oxides has been developed. It consists at the condensation of 2-unsubstituted imidazole N-oxides with aldehydes and CH-acids. This method permits broad variations in the structure of starting materials. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2017.10.026