Mechanoenzymatic resolution of racemic chiral amines, a green technique for the synthesis of pharmaceutical building blocks

Very recently, several successful biocatalytic processes using mechanical activation to carry out enantioselective reactions have been reported. The present work describes the use of Candida antarctica Lipase B (CALB) in the kinetic resolution of racemic chiral amines by means of High-Speed Ball Mil...

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Bibliographic Details
Published in:Tetrahedron 2018-11, Vol.74 (44), p.6453-6458
Main Authors: Pérez-Venegas, Mario, Juaristi, Eusebio
Format: Article
Language:English
Subjects:
CALB
Green chemistry
Kinetic resolution
Mechanochemistry
Rasagiline
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Summary:Very recently, several successful biocatalytic processes using mechanical activation to carry out enantioselective reactions have been reported. The present work describes the use of Candida antarctica Lipase B (CALB) in the kinetic resolution of racemic chiral amines by means of High-Speed Ball Milling (HSBM), minimizing the use of solvent and reducing reaction times. This approach provides an efficient and easily scalable strategy that was used for the green synthesis of enantiopure Rasagiline, as an illustrative example. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.09.029