Triphenyl borate catalyzed synthesis of amides from carboxylic acids and amines

Herein we report triphenyl borate as a new catalyst for synthesis of amides by catalytic condensation of carboxylic acids and amines. Our protocol is applicable for synthesis of wide range of amides furnishing excellent yields up to 92%. In addition developed method requires low catalyst loading, sh...

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Bibliographic Details
Published in:Tetrahedron 2018-11, Vol.74 (48), p.6954-6958
Main Authors: Ghorpade, Seema A., Sawant, Dinesh N., Sekar, Nagaiyan
Format: Article
Language:English
Subjects:
Amidation
Amides
Borate ester
Condensation
Peptides
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Summary:Herein we report triphenyl borate as a new catalyst for synthesis of amides by catalytic condensation of carboxylic acids and amines. Our protocol is applicable for synthesis of wide range of amides furnishing excellent yields up to 92%. In addition developed method requires low catalyst loading, short time, less amount of solvent, works under air atmosphere and notably no need of azeotropic reflux using special Dean Stark apparatus or molecular sieves. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.10.030