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Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenative coupling

A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium...

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Bibliographic Details
Published in:Tetrahedron 2019-03, Vol.75 (12), p.1605-1611
Main Authors: Gu, Chang-Xue, Chen, Wen-Wen, Xu, Bin, Xu, Ming-Hua
Format: Article
Language:English
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Summary:A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium catalysis. The method is among the most straightforward and convenient ways to access these fused polyheterocycles. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2018.11.066