Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderat...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron 2019-06, Vol.75 (25), p.3382-3386
Main Authors: Ozaki, Kaori, Iwasaki, Arihiro, Suenaga, Kiyotake, Teruya, Toshiaki
Format: Article
Language:English
Subjects:
Caldora penicillata
Cyclic depsipeptide
Marine natural products
Serine protease inhibition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 μM. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2019.04.046