Synthesis of isoindolo[1,2-a]isoquinoline and isoindolo[2,1-a]quinoline derivatives via trifluoroacetic acid-mediated cascade reactions

Condensation of methyl 2-acylbenzoates with 2-arylethanamines or 2-acylanilines in the presence of trifluoroacetic acid resulted in the formation of isoindolo[1,2-a]isoquinolines or isoindolo[2,1-a]quinolines, respectively, in moderate to excellent isolated yields. [Display omitted]

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Bibliographic Details
Published in:Tetrahedron 2021-07, Vol.93, p.132280, Article 132280
Main Authors: Huang, Zhuo, Meng, Yonggang, Wu, Yangang, Song, Chuanjun, Chang, Junbiao
Format: Article
Language:English
Subjects:
Cascade reaction
isoindolo[1,2-a]isoquinoline
isoindolo[2,1-a]quinoline
Trifluoroacetic acid
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Description
Summary:Condensation of methyl 2-acylbenzoates with 2-arylethanamines or 2-acylanilines in the presence of trifluoroacetic acid resulted in the formation of isoindolo[1,2-a]isoquinolines or isoindolo[2,1-a]quinolines, respectively, in moderate to excellent isolated yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2021.132280