KOtBu-catalyzed protocol for the post-ugi synthesis of spiro-γ-lactam-pyrrolo[2,3-b]quinoline derivatives in one-pot

This presentation describes an efficient and facile preparation of a series of new spiro-γ-lactam-pyrrolo[2,3-b]quinoline scaffolds. The Ugi adducts obtained via four-component condensation of 2-chloroquinoline-3-carbaldehydes, amines, trans-cinnamic acids and isocyanides underwent metal-free KOtBu-...

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Bibliographic Details
Published in:Tetrahedron 2023-06, Vol.140, p.133452, Article 133452
Main Authors: Fallahnezhad, Maryam, Ghandi, Mehdi, Rahimi, Shahnaz, Abbasi, Alireza
Format: Article
Language:English
Subjects:
Bis-annulation processes
Post-ugi reactions
Spiro-γ-lactam-pyrrolo[2,3-b]quinolone
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Summary:This presentation describes an efficient and facile preparation of a series of new spiro-γ-lactam-pyrrolo[2,3-b]quinoline scaffolds. The Ugi adducts obtained via four-component condensation of 2-chloroquinoline-3-carbaldehydes, amines, trans-cinnamic acids and isocyanides underwent metal-free KOtBu-catalyzed bis-annulation processes to afford a diastereomeric mixture of the desired tetracyclic building blocks in moderate to good yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2023.133452