A recent update on the environment friendly methodologies to synthesize bis(indolyl)methane and 3,3-di(3-indolyl)-2-indolone derivatives

• Published in: Tetrahedron 2023-11, Vol.148, p.133679, Article 133679
• Main Authors: Kamboj, Priya, Tyagi, Vikas
• Format: Article
• Language: English
• Subjects: 3,3-Di(3-indolyl)-2-indolone; Bis(indolyl)methane; Green approaches; Metal-free; Water
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2023.133679

Indole, widely recognized as a versatile category of heterocyclic frameworks that contain nitrogen is extensively employed in the synthesis of various organic compounds due to their diverse utility. The agrochemical and pharmaceutical sectors demand novel and effective synthetic methodologies for indole derivatives owing to their diverse array of applications. Moreover, this scaffold has significant advantages in the field of drug discovery due to its diverse range of applications, including antiviral, antifungal, anti-cancer, anti-inflammatory, anti-malarial, and anti-oxidant properties. In this context, several efforts have been made to synthesize indole derivatives. Nevertheless, the application of Lewis acids or bases, along with transition-metal catalysts, in these methodologies does not adhere to the principles and goals of green chemistry. In the current era, there has been a significant focus on the research and development of innovative environmentally-friendly methodologies for synthesizing indole derivatives. This review examines the progress achieved in the domain of environmentally sustainable synthesis of bis(indolyl)methane and 3,3-bis(1H-indol-3-yl) derivatives over the past three years. [Display omitted]