Inexpensive and mild hydrogenation condition: Raney Ni-catalyzed reduction of alkenes and alkynes using Et3SiH at ambient temperature

The Raney Ni-catalyzed hydrogenation of alkenes and alkynes has been developed. Et3SiH was chosen as the reductant. Substrates with various substituents were reduced at ambient temperature, affording good to excellent yields. No pressure reactor, heating, or inert atmosphere is required and the cata...

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Bibliographic Details
Published in:Tetrahedron 2024-06, Vol.160, p.134040, Article 134040
Main Authors: Liu, Cheng-Hang, Xu, Mengyang, Luo, Qiyun, Wang, Ziyan, Tan, Wenyue, Zhao, Xingzeng, Jia, Xiaodong
Format: Article
Language:English
Subjects:
Et3SiH
Hydrogenation
Inexpensive and mild condition
Raney Ni
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Summary:The Raney Ni-catalyzed hydrogenation of alkenes and alkynes has been developed. Et3SiH was chosen as the reductant. Substrates with various substituents were reduced at ambient temperature, affording good to excellent yields. No pressure reactor, heating, or inert atmosphere is required and the catalyst can be removed/recycled by simple filtration. Raney Ni-catalyzed hydrogenation of alkenes and alkynes using Et3SiH as the reductant at ambient temperature. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2024.134040