1,2,3-Triazole nilotinib analogues: Synthesis and Cytotoxic activity

Using the CuAAC reaction as a key step, a novel series of Nilotinib analogues was prepared by replacing the imidazole ring in the Nilotinib molecule with 1,2,3-triazole moiety via a divergent synthetic approach. The synthesized compounds were tested for cytotoxic activity against a series of tumor c...

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Bibliographic Details
Published in:Tetrahedron 2024-11, Vol.167, p.134284, Article 134284
Main Authors: Almazán-Sánchez, Leticia, Ramírez-Apan, María Teresa, Morales-Morales, David, García-Eleno, Marco A., Cuevas-Yañez, Erick
Format: Article
Language:English
Subjects:
1,2,3-Triazole
Click chemistry
Cytotoxic activity
Nilotinib analogues
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Summary:Using the CuAAC reaction as a key step, a novel series of Nilotinib analogues was prepared by replacing the imidazole ring in the Nilotinib molecule with 1,2,3-triazole moiety via a divergent synthetic approach. The synthesized compounds were tested for cytotoxic activity against a series of tumor cell lines which included U251, PC-3, K562, HCT-15, MCF-7 and SKLU. Inhibition growth up to 85.6 % was observed for some compounds. [Display omitted]
ISSN:0040-4020
DOI:10.1016/j.tet.2024.134284