An easy route to 4-substituted 2-oxazolidinones from prochiral-1,3-diols

Graphic A novel synthesis of 4-substituted 2-oxazolidinones starting from prochiral-1,3-diols has been developed. After enzymatic desymmetrisation the resulting monoacetyled diols were transformed into amides. A Hofmann rearrangement of these amides led to 2-oxazolidinones

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2004-04, Vol.15 (8), p.1331-1333
Main Authors: Allali, Hocine, Tabti, Boufeldja, Alexandre, Christian, Huet, François
Format: Article
Language:English
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Summary:Graphic A novel synthesis of 4-substituted 2-oxazolidinones starting from prochiral-1,3-diols has been developed. After enzymatic desymmetrisation the resulting monoacetyled diols were transformed into amides. A Hofmann rearrangement of these amides led to 2-oxazolidinones
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2004.02.034