Synthesis of aminoethanethiol trityl ether ligands for ruthenium-catalysed asymmetric transfer hydrogenation

[Display omitted] A series of chiral aminoethanethiol ethers was synthesised by the regioselective and stereospecific ring opening of the ( R)-trityl(thiiranylmethyl)ether and examined in the hydrogen transfer reduction of different aromatic ketones. High conversions (>99%) and enantioselectiviti...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2004-11, Vol.15 (21), p.3413-3418
Main Authors: Harfouche, Joyce, Hérault, Damien, Tommasino, M. Lorraine, Pellet-Rostaing, Stéphane, Lemaire, Marc
Format: Article
Language:English
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Summary:[Display omitted] A series of chiral aminoethanethiol ethers was synthesised by the regioselective and stereospecific ring opening of the ( R)-trityl(thiiranylmethyl)ether and examined in the hydrogen transfer reduction of different aromatic ketones. High conversions (>99%) and enantioselectivities (91%) were obtained under mild reaction conditions.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2004.08.017