A novel benzoyl-type fluorous protecting group for use in fluorous synthesis

[Display omitted] TfBz–OH, a novel benzoyl-type fluorous protecting reagent, has been easily prepared. It was found that the TfBz (trisfluorous chain-type benzoyl) group can be successfully introduced onto a hydroxyl function, removed in high yield, and recycled after deprotection. The use of the Tf...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2005-01, Vol.16 (1), p.3-6
Main Authors: Miura, Tsuyoshi, Satoh, Ai, Goto, Kohtaro, Murakami, Yasuoki, Imai, Nobuyuki, Inazu, Toshiyuki
Format: Article
Language:English
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Summary:[Display omitted] TfBz–OH, a novel benzoyl-type fluorous protecting reagent, has been easily prepared. It was found that the TfBz (trisfluorous chain-type benzoyl) group can be successfully introduced onto a hydroxyl function, removed in high yield, and recycled after deprotection. The use of the TfBz group makes it possible to synthesize an oligosaccharide by minimal column chromatography purification, because each synthetic intermediate is easily purified simply by fluorous-organic solvent extraction.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2004.11.050