Synthesis of enantiomerically pure β,β-diphenylalanine (Dip) and fluorenylglycine (Flg)

A new strategy for the preparation of both enantiomers of two phenylalanine analogues, β,β-diphenylalanine and fluorenylglycine, has been developed. The combination of a high yielding racemic synthesis and a very efficient resolution procedure has provided significant amounts of each amino acid in e...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2006-09, Vol.17 (16), p.2393-2400
Main Authors: Royo, Soledad, Jiménez, Ana I., Cativiela, Carlos
Format: Article
Language:English
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Summary:A new strategy for the preparation of both enantiomers of two phenylalanine analogues, β,β-diphenylalanine and fluorenylglycine, has been developed. The combination of a high yielding racemic synthesis and a very efficient resolution procedure has provided significant amounts of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis. This methodology can be easily applied to the preparation of larger quantities of enantiopure compounds.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2006.08.007