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Baker’s yeast-mediated synthesis of ( R)- and ( S)-heteroaryl-ethane-1,2-diols

Baker’s yeast-mediated enantioselective bioreduction of 1-(heteroaryl)-2-hydroxyethanones and 2-acetoxy-1-(hetero-aryl)ethanones was used for the enantioselective synthesis of both ( R)- and ( S)-benzofuranyl-, benzo[ b]thiophenyl- and benzo[ d]thiazolyl-ethane-1,2-diols.

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2008-08, Vol.19 (16), p.1959-1964
Main Authors: Podea, Paula Veronica, Paizs, Csaba, Toşa, Monica Ioana, Irimie, Florin Dan
Format: Article
Language:English
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Summary:Baker’s yeast-mediated enantioselective bioreduction of 1-(heteroaryl)-2-hydroxyethanones and 2-acetoxy-1-(hetero-aryl)ethanones was used for the enantioselective synthesis of both ( R)- and ( S)-benzofuranyl-, benzo[ b]thiophenyl- and benzo[ d]thiazolyl-ethane-1,2-diols.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2008.07.030