Indole-olefin-oxazoline (IndOlefOx)-ligands: synthesis and utilization in asymmetric Rh-catalyzed conjugate addition

The synthesis and utility of novel indole-olefin-oxazoline (IndOlefOx)-ligands are described. The use of these ligands was demonstrated in rhodium catalyzed asymmetric conjugate additions between 2-cyclopentenone, 2-cyclohexenone, and 2-cycloheptenone with different boron reagents with good yields a...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2011-02, Vol.22 (4), p.468-475
Main Authors: Kuuloja, Noora, Tois, Jan, Franzén, Robert
Format: Article
Language:English
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Summary:The synthesis and utility of novel indole-olefin-oxazoline (IndOlefOx)-ligands are described. The use of these ligands was demonstrated in rhodium catalyzed asymmetric conjugate additions between 2-cyclopentenone, 2-cyclohexenone, and 2-cycloheptenone with different boron reagents with good yields and enantioselectivities of up to 94%.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2011.02.020