A novel trifunctional organocatalyst for the asymmetric aldol reaction: a facile enantioselective synthesis of β-hydroxyketones

A new l-prolinamide trifunctional catalyst has been developed for the enantioselective aldol reaction of various aromatic and aliphatic aldehydes with acetone. This method provides high yields of β-hydroxyketones (up to 90%) with good enantioselectivity (up to 92%) at a low catalyst loading (10 mol...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2011-04, Vol.22 (8), p.881-886
Main Authors: Subba Reddy, B.V., Bhavani, K., Raju, A., Yadav, J.S.
Format: Article
Language:English
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Summary:A new l-prolinamide trifunctional catalyst has been developed for the enantioselective aldol reaction of various aromatic and aliphatic aldehydes with acetone. This method provides high yields of β-hydroxyketones (up to 90%) with good enantioselectivity (up to 92%) at a low catalyst loading (10 mol %).
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2011.05.001