AZT-prolinamide: the nucleoside derived pyrrolidine catalysts for asymmetric aldol reactions using water as solvent

New pyrrolidine catalysts based on a nucleoside and proline, AZT-prolinamides, were synthesized and successfully employed for the enantioselective direct aldol reaction of aldehydes with ketones. These catalysts proved to be effective in promoting the reaction, in additive free water media with 15mo...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2014-10, Vol.25 (18-19), p.1340-1345
Main Authors: Naresh, Tumma, Kumar, Togapur Pavan, Haribabu, Kothapalli, Chandrasekhar, Srivari
Format: Article
Language:English
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Summary:New pyrrolidine catalysts based on a nucleoside and proline, AZT-prolinamides, were synthesized and successfully employed for the enantioselective direct aldol reaction of aldehydes with ketones. These catalysts proved to be effective in promoting the reaction, in additive free water media with 15mol% loading. The products, β-hydroxy carbonyl compounds were obtained in high yields and stereoselectivities.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2014.08.007