Synthesis of new conformationally rigid paramagnetic α-amino acids

A pyrroline nitroxide based cyclic tetrasubstituted α-amino acid and paramagnetic homoproline and their derivatives are described. Introduction of a new paramagnetic protecting group to follow the incorporation of an amino acid into peptides by EPR is also suggested. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2003-12, Vol.44 (51), p.9213-9217
Main Authors: Balog, Mária, Kálai, Tamás, Jekő, József, Berente, Zoltán, Steinhoff, Heinz-Jürgen, Engelhard, Martin, Hideg, Kálmán
Format: Article
Language:English
Subjects:
amino acids
nitroxides
protecting group
TOAC
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Description
Summary:A pyrroline nitroxide based cyclic tetrasubstituted α-amino acid and paramagnetic homoproline and their derivatives are described. Introduction of a new paramagnetic protecting group to follow the incorporation of an amino acid into peptides by EPR is also suggested. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.10.020