Brevetoxin B5, a new brevetoxin analog isolated from cockle Austrovenus stutchburyi in New Zealand, the marker for monitoring shellfish neurotoxicity

Graphic A new brevetoxin analog, brevetoxin B5 (BTX-B5) was isolated together with BTX-B1 and PbTx-3 from the New Zealand cockle Austrovenus stutchburyi harvested at an outbreak of neurotoxic shellfish poisoning early in 1993. The structure was elucidated by comparison of its spectral data (NMR and...

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Bibliographic Details
Published in:Tetrahedron letters 2004, Vol.45 (1), p.29-33
Main Authors: Ishida, Hitoshi, Nozawa, Akira, Hamano, Hiromitsu, Naoki, Hideo, Fujita, Tsuyoshi, Kaspar, Heinrich F., Tsuji, Kuniro
Format: Article
Language:English
Subjects:
brevetoxin
BTX-B5
New Zealand
NSP
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Summary:Graphic A new brevetoxin analog, brevetoxin B5 (BTX-B5) was isolated together with BTX-B1 and PbTx-3 from the New Zealand cockle Austrovenus stutchburyi harvested at an outbreak of neurotoxic shellfish poisoning early in 1993. The structure was elucidated by comparison of its spectral data (NMR and CAD FAB MS/MS) with those of BTX-B1 and PbTx-2, and confirmed by synthesis from PbTx-2 with SeO 2 and H 2O 2. It was detected in the toxic greenshell mussel Perna canaliculus and Pacific oyster Crassostrea gigas collected at the same time.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.10.124