Synthesis of calix[4]arene library substituted with peptides at the upper rim

A fluorescence-labeled calix[4]arene library substituted with peptides at the upper rim was synthesized. Screening of the library for binding a dye-labeled oligopeptide indicated that some peptidocalix[4]arenes selectively bind the oligopeptide. The chemosensitivity of the library members for a targ...

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Bibliographic Details
Published in:Tetrahedron letters 2004-01, Vol.45 (3), p.561-564
Main Authors: Hioki, Hideaki, Ohnishi, Yumiko, Kubo, Miwa, Nashimoto, Emi, Kinoshita, Yukinori, Samejima, Miho, Kodama, Mitsuaki
Format: Article
Language:English
Subjects:
Binding assay
Calixarenes
Chemosensors
Combinatorial library
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Summary:A fluorescence-labeled calix[4]arene library substituted with peptides at the upper rim was synthesized. Screening of the library for binding a dye-labeled oligopeptide indicated that some peptidocalix[4]arenes selectively bind the oligopeptide. The chemosensitivity of the library members for a target peptide was also investigated. A fluorescence-labeled calix[4]arene library substituted with peptides at the upper rim was synthesized. Screening of the library for binding a dye-labeled oligopeptide indicated that some peptidocalix[4]arenes selectively bind the oligopeptide. The chemosensitivity of the library members for a target peptide was also investigated.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.10.215