Synthesis, evaluation and incorporation into liposomes of 4-functionalised-2,5-diphenyloxazole derivatives for application in scintillation proximity assays

4-Functionalised-2,5-diphenyloxazole derivatives (‘scintilipids’) have been synthesised and evaluated for their ability to scintillate and to assemble with other lipids, into liposomes that scintillate (‘scintiliposomes’). The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is descr...

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Bibliographic Details
Published in:Tetrahedron letters 2004-03, Vol.45 (10), p.2163-2166
Main Authors: McCairn, Mark C, Culliford, Steven J, Kozlowski, Roland Z, Sutherland, Andrew J
Format: Article
Language:English
Subjects:
Oxazoles
Scintillation
SPA
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Summary:4-Functionalised-2,5-diphenyloxazole derivatives (‘scintilipids’) have been synthesised and evaluated for their ability to scintillate and to assemble with other lipids, into liposomes that scintillate (‘scintiliposomes’). The preparation of a series of 4-functionalised-2,5-diphenyloxazoles is described. The scintillating efficiency of each of these ‘scintilipid’ molecules has been evaluated in the presence of ionising radiation. Each ‘scintilipid’ has been assessed for the ability to assemble, with other lipids, into liposomes, under a variety of preparative conditions. Each liposomal preparation has been monitored for the ability to scintillate in the presence of ionising radiation. The optimal ‘scintilipid’, both in terms of effective liposomal formation and scintillation efficiency, has been determined.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.034