First synthesis of (±)-bis-homosarkomycin ethyl ester

Graphic A five step synthesis of (±)-bis-homosarkomycin ethyl ester 6 has been achieved starting from commercially available ethyl phosphonoacetate and ethyl 5-bromovalerate. The successful synthetic approach to 6 uses α-methylene pimelate 3 as a key intermediate.

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2004-03, Vol.45 (10), p.2049-2050
Main Authors: Samarat, Ali, Landais, Yannick, Amri, Hassen
Format: Article
Language:English
Subjects:
Cyclisation
Functional phosphonoacetate
Horner–Wadsworth–Emmons reaction
Michael addition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Graphic A five step synthesis of (±)-bis-homosarkomycin ethyl ester 6 has been achieved starting from commercially available ethyl phosphonoacetate and ethyl 5-bromovalerate. The successful synthetic approach to 6 uses α-methylene pimelate 3 as a key intermediate.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.079