Indium-mediated mild and facile method for the synthesis of amides

Graphic Indium-mediated coupling reactions of acyl chlorides and amines for the synthesis of amide bonds are described. The reaction afforded high yields of the desired amides under mild and neutral conditions, and it was applicable also to the preparation of peptides without epimerization.

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Bibliographic Details
Published in:Tetrahedron letters 2004-03, Vol.45 (11), p.2285-2287
Main Authors: Cho, Dae Hyan, Jang, Doo Ok
Format: Article
Language:English
Subjects:
Amides
Indium
Peptides
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Description
Summary:Graphic Indium-mediated coupling reactions of acyl chlorides and amines for the synthesis of amide bonds are described. The reaction afforded high yields of the desired amides under mild and neutral conditions, and it was applicable also to the preparation of peptides without epimerization.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.114