A facile tandem construction of C–O and C–C bonds: a novel one-pot transformation of Baylis–Hillman adducts into 2-benzoxepines

Graphic A facile and one-pot synthesis of 2-benzoxepines, from Baylis–Hillman adducts that is, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates, via treatment with HCHO in the presence of concd H 2SO 4, involving tandem construction of C–O and C–C bonds via Prins-type and Friedel–Crafts reactions, is d...

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Bibliographic Details
Published in:Tetrahedron letters 2004-04, Vol.45 (15), p.3081-3083
Main Authors: Basavaiah, Deevi, Sharada, Duddu S., Veerendhar, Ainelly
Format: Article
Language:English
Subjects:
2-Benzoxepines
Baylis–Hillman chemistry
Friedel–Crafts reaction
para-Formaldehyde
Prins-type reaction
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Summary:Graphic A facile and one-pot synthesis of 2-benzoxepines, from Baylis–Hillman adducts that is, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates, via treatment with HCHO in the presence of concd H 2SO 4, involving tandem construction of C–O and C–C bonds via Prins-type and Friedel–Crafts reactions, is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.02.107