Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells

[Display omitted] It was reported that the somatostatin analog TT-232, d-Phe- c(Cys-Tyr- d-Trp-Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin a...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2004-08, Vol.45 (33), p.6323-6327
Main Authors: Miyazaki, Anna, Yokoi, Toshio, Tachibana, Yoshifumi, Enomoto, Riyo, Lee, Eibai, Bokonyi, Gyongyi, Keri, Gyorgy, Tsuda, Yuko, Okada, Yoshio
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] It was reported that the somatostatin analog TT-232, d-Phe- c(Cys-Tyr- d-Trp-Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr- d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.06.105