Synthesis of functionalized nitrogen heterocycles from β- and γ-amino acids by radical decarboxylation

[Display omitted] The radical decarboxylation of β- and γ-amino acids on treatment with PhI(OAc) 2–I 2 is a mild and efficient methodology to synthesize halogenated or oxygenated nitrogen heterocycles. The reaction was applied to the synthesis of bioactive products, such as opioid analogues, iminosu...

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Bibliographic Details
Published in:Tetrahedron letters 2004-09, Vol.45 (37), p.6841-6845
Main Authors: Boto, Alicia, Hernández, Rosendo, de León, Yolanda, Murguı́a, José R., Rodrı́guez-Afonso, Abigail
Format: Article
Language:English
Subjects:
Amino acids
Antifungic
Arylpiperidines
Decarboxylation
Piperidines
Pyrrolidines
Radicals
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Summary:[Display omitted] The radical decarboxylation of β- and γ-amino acids on treatment with PhI(OAc) 2–I 2 is a mild and efficient methodology to synthesize halogenated or oxygenated nitrogen heterocycles. The reaction was applied to the synthesis of bioactive products, such as opioid analogues, iminosugars and new antifungic agents.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.07.111