Violatinctamine, a new heterocyclic compound from the marine tunicate Cystodytes cf. violatinctus

A new alkaloid designated violatinctamine was isolated from the tunicate Cystodytes cf. violatinctus collected in Kenya. Violatinctamine has a unique heterocyclic skeleton, which combines a benzothiazole unit and a dihydroisoquinoline unit. A new alkaloid designated violatinctamine and four known me...

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Bibliographic Details
Published in:Tetrahedron letters 2004-10, Vol.45 (42), p.7925-7928
Main Authors: Chill, Liat, Rudi, Amira, Benayahu, Yehuda, Kashman, Yoel
Format: Article
Language:English
Subjects:
Alkaloid
Benzothiazole
Heterocyclic
Marine tunicate
Violatinctamine
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Summary:A new alkaloid designated violatinctamine was isolated from the tunicate Cystodytes cf. violatinctus collected in Kenya. Violatinctamine has a unique heterocyclic skeleton, which combines a benzothiazole unit and a dihydroisoquinoline unit. A new alkaloid designated violatinctamine and four known metabolites were isolated from the tunicate Cystodytes cf. violatinctus collected in Kenya. Violatinctamine has a unique heterocyclic skeleton, which combines a benzothiazole unit and a dihydroisoquinoline unit. The structure of violatinctamine was elucidated by interpretation of MS results as well as 1D and 2D NMR spectra of the alkaloid and of its O, O′-dimethyl derivative. Analysis of the spectral information also implies that violatinctamine exists as a mixture of two tautomers—the imino-phenol and the amino quinone-methide.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.08.137