Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction

Using a Design of Experiments approach the optimization of a Heck reaction catalyzed by a solid-supported sulfur-containing palladacycle was improved from 30% with large observable leaching to 88% with no observable leaching. Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a...

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Bibliographic Details
Published in:Tetrahedron letters 2004-10, Vol.45 (44), p.8239-8243
Main Authors: McNamara, Catherine Anne, King, Frank, Bradley, Mark
Format: Article
Language:English
Subjects:
Design
Palladium
Polymer
Supported
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Summary:Using a Design of Experiments approach the optimization of a Heck reaction catalyzed by a solid-supported sulfur-containing palladacycle was improved from 30% with large observable leaching to 88% with no observable leaching. Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0 TM.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.016