Asymmetric transfer hydrogenation of aromatic ketones catalyzed by the iridium hydride complex under ambient conditions

[Display omitted] The chiral Ir catalytic system generated in situ from iridium hydride complex and chiral diaminodiphosphine ligand was employed in asymmetric transfer hydrogenation of aromatic ketones to give the corresponding optically active alcohols, with up to 99% ee in high yield were obtaine...

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Bibliographic Details
Published in:Tetrahedron letters 2004-11, Vol.45 (45), p.8415-8418
Main Authors: Chen, Jian-shan, Li, Yan-yun, Dong, Zhen-rong, Li, Bao-zhu, Gao, Jing-xing
Format: Article
Language:English
Subjects:
Aromatic ketone
Asymmetric transfer hydrogenation
Chiral ligand
Iridium hydride complex
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Summary:[Display omitted] The chiral Ir catalytic system generated in situ from iridium hydride complex and chiral diaminodiphosphine ligand was employed in asymmetric transfer hydrogenation of aromatic ketones to give the corresponding optically active alcohols, with up to 99% ee in high yield were obtained even when the substrate-to-catalyst molar ratio reached 10000:1.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.088